Dimidium bromide

Names

[ CAS No. ]:
518-67-2

[ Name ]:
Dimidium bromide

[Synonym ]:
Dimidiniumbromide
Phenanthridinium1553
DiMidiuM BroMide
DIMIDIUM BROMIDE 1/2 H2O
Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide (1:1)
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide Trypadine
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide
3,8-diamino-5-methyl-6-phenyl-phenanthridinium,bromide
MFCD00011757
Phenanthridiniumcompound1553
6c46
EINECS 208-256-7
TRYPADINE

Biological Activity

[Description]:

Dimidium bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Melting Point ]:
243-248 °C(lit.)

[ Molecular Formula ]:
C₂₀H₁₈BrN₃

[ Molecular Weight ]:
380.281

[ Exact Mass ]:
379.068390

[ PSA ]:
55.92000

[ LogP ]:
1.81530

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF7960500

CHEMICAL NAME :: Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide

CAS REGISTRY NUMBER :: 518-67-2

LAST UPDATED :: 199512

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H18-N3.Br

MOLECULAR WEIGHT :: 380.32

WISWESSER LINE NOTATION :: T B666 HKJ EZ H1 IR& LZ &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 61 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 5,261,1950 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 mg/kg/5D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6236 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 67 (estimated) No. of Female Employees: 34 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
SF7960500

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy.

Int. J. Biochem. 14 , 493, (1982)

1. The absorption spectrum of three phenanthridine drugs (ethidium, dimidium and prothidium bromide) bound to natural DNAs of differing G-C content were obtained using a novel mixing scheme and analys...

[Effect of some DNA-intercalators and antioxidants on the phagosome- lysosome fusion and F-actin content in murine peritoneal macrophages].

Tsitologiia 40(6) , 585-90, (1998)

Effect of DNA-intercalators ethidium bromide (EB, 0.005 and 0.015 mM) and dimidium bromide (DB, 0.005 and 0.010 mM) and antioxidative compounds acetylsalicylic acid (ASA, 0.05 and 0.50 mM) and beta-ca...

[The toxicity of sanguinarine compared to a number of other DNA-tropic compounds for ethidium bromide-sensitive and -resistant transformed murine fibroblasts in culture].

Tsitologiia 31(11) , 1363-8, (1989)

A natural DNA-intercalator plant benzo-c-phenanthridine alkaloid sanguinarine is more toxic for mouse transformed fibroblast L-cells in culture than synthetic DNA-intercalator ethidium bromide (EtB) a...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.