Dimidium bromide
Names
[ CAS No. ]:
518-67-2
[ Name ]:
Dimidium bromide
[Synonym ]:
Dimidiniumbromide
Phenanthridinium1553
DiMidiuM BroMide
DIMIDIUM BROMIDE 1/2 H2O
Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide (1:1)
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide Trypadine
3,8-Diamino-5-methyl-6-phenylphenanthridinium bromide
3,8-diamino-5-methyl-6-phenyl-phenanthridinium,bromide
MFCD00011757
Phenanthridiniumcompound1553
6c46
EINECS 208-256-7
TRYPADINE
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Melting Point ]:
243-248 °C(lit.)
[ Molecular Formula ]:
C20H18BrN3
[ Molecular Weight ]:
380.281
[ Exact Mass ]:
379.068390
[ PSA ]:
55.92000
[ LogP ]:
1.81530
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SF7960500
- CHEMICAL NAME :
- Phenanthridinium, 3,8-diamino-5-methyl-6-phenyl-, bromide
- CAS REGISTRY NUMBER :
- 518-67-2
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H18-N3.Br
- MOLECULAR WEIGHT :
- 380.32
- WISWESSER LINE NOTATION :
- T B666 HKJ EZ H1 IR& LZ &E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 61 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 5,261,1950 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 10 mg/kg/5D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,65,1946 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6236 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 67 (estimated) No. of Female Employees: 34 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
SF7960500
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Int. J. Biochem. 14 , 493, (1982)
1. The absorption spectrum of three phenanthridine drugs (ethidium, dimidium and prothidium bromide) bound to natural DNAs of differing G-C content were obtained using a novel mixing scheme and analys...
[Effect of some DNA-intercalators and antioxidants on the phagosome- lysosome fusion and F-actin content in murine peritoneal macrophages].Tsitologiia 40(6) , 585-90, (1998)
Effect of DNA-intercalators ethidium bromide (EB, 0.005 and 0.015 mM) and dimidium bromide (DB, 0.005 and 0.010 mM) and antioxidative compounds acetylsalicylic acid (ASA, 0.05 and 0.50 mM) and beta-ca...
[The toxicity of sanguinarine compared to a number of other DNA-tropic compounds for ethidium bromide-sensitive and -resistant transformed murine fibroblasts in culture].Tsitologiia 31(11) , 1363-8, (1989)
A natural DNA-intercalator plant benzo-c-phenanthridine alkaloid sanguinarine is more toxic for mouse transformed fibroblast L-cells in culture than synthetic DNA-intercalator ethidium bromide (EtB) a...