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LHRH (4-10) acetate salt

Names

[ CAS No. ]:
51776-33-1

[ Name ]:
LHRH (4-10) acetate salt

[Synonym ]:
Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Luteinizing hormone releasing hormone Fragment 4-10
LH-RH Fragment 4-10
LHRH (4-10)
H-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Biological Activity

[Description]:

LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor
Research Areas >> Endocrinology

[In Vitro]

The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor)[1]. LH-RH (4-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 23 pM[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C33H53N11O9

[ Molecular Weight ]:
747.84200

[ Exact Mass ]:
747.40300

[ PSA ]:
337.28000

[ LogP ]:
0.21070

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
60

[ Safety Phrases ]:
53-22-36/37/39-45

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Related Compounds

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