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Sennidin B

Names

[ CAS No. ]:
517-44-2

[ Name ]:
Sennidin B

[Synonym ]:
(9R,9'S)-4,4',5,5'-Tetrahydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid
1,4-Dichlorobutane-2,3-acetonide
meso-4,5-Bis-chlormethyl-2,2-dimethyl-dioxolan
Sennidin B
[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-, (9R,9'S)-

Biological Activity

[Description]:

Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation [1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Metabolic Disease

[References]

[1]. Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16(8):18439-53.

[2]. Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
801.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H18O10

[ Molecular Weight ]:
538.458

[ Flash Point ]:
452.6±30.8 °C

[ Exact Mass ]:
538.090027

[ PSA ]:
189.66000

[ LogP ]:
8.24

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.806

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
22

[ Safety Phrases ]:
22-45

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds