tipepidine
Names
[ CAS No. ]:
5169-78-8
[ Name ]:
tipepidine
[Synonym ]:
3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine
Bitiodin
Asverin
(1-Methyl-3-piperidylidene)di(2-thienyl)methane
Tipepidine [INN:DCF]
Tipepidine
3-(Di-[2]thienyl-methylen)-1-methyl-piperidin
Tipepidina [INN-Spanish]
Tipedine
Tipepidinum [INN-Latin]
(1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat
CR/662
AT 327
3-(di-[2]thienyl-methylene)-1-methyl-piperidine
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 7.0 μM (dopamine D2 receptor)[1]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.1947 (rough estimate)
[ Boiling Point ]:
bp4-5 178-184°
[ Melting Point ]:
64-65°
[ Molecular Formula ]:
C15H17NS2
[ Molecular Weight ]:
275.43200
[ Exact Mass ]:
275.08000
[ PSA ]:
59.72000
[ LogP ]:
4.27500
[ Index of Refraction ]:
1.5300 (estimate)
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM7870000
- CHEMICAL NAME :
- Piperidine, 3-(di-2-thienylmethylene)-1-methyl-
- CAS REGISTRY NUMBER :
- 5169-78-8
- BEILSTEIN REFERENCE NO. :
- 0212554
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C15-H17-N-S2
- MOLECULAR WEIGHT :
- 275.45
- WISWESSER LINE NOTATION :
- T6N CYTJ A1 CUY- BT5SJ&- BT5SJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 867 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 294 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - excitement Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,1482,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 308 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 44 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%