N-iodosuccinimide
Names
[ CAS No. ]:
516-12-1
[ Name ]:
N-iodosuccinimide
[Synonym ]:
succinimide, N-iodo-
N-Iodosuccinimide
1-Iodopyrrolidine-2,5-dione
1-Iodo-2,5-pyrrolidinedione
N-Iodo succinimide
NIS
2,5-Pyrrolidinedione, 1-iodo-
N-Iodosuccinimide (NIS)
MFCD00005512
EINECS 208-221-6
Chemical & Physical Properties
[ Density]:
2.3±0.1 g/cm3
[ Boiling Point ]:
249.6±23.0 °C at 760 mmHg
[ Melting Point ]:
202-206 °C(lit.)
[ Molecular Formula ]:
C4H4INO2
[ Molecular Weight ]:
224.984
[ Flash Point ]:
104.8±22.6 °C
[ Exact Mass ]:
224.928665
[ PSA ]:
37.38000
[ LogP ]:
-0.21
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.653
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
decomposes
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WN2817000
- CHEMICAL NAME :
- Succinimide, N-iodo-
- CAS REGISTRY NUMBER :
- 516-12-1
- BEILSTEIN REFERENCE NO. :
- 0113917
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C4-H4-I-N-O2
- MOLECULAR WEIGHT :
- 224.99
- WISWESSER LINE NOTATION :
- T5VNVTJ BI
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02815
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
WN2817000
[ HS Code ]:
29251995
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Mucosal Immunol. 8 , 1083-98, (2015)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, ha...
Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.PLoS ONE 10(2) , e0116509, (2015)
E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to i...
Differential expression of CART in feeding and reward circuits in binge eating rat model.Behav. Brain Res. 291 , 219-31, (2015)
Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies invest...