6-[[(1,1-Dimethylethoxy)carbonyl]amino]hexanoic acid 2,5-dioxo-1-pyrrolidinyl ester

Names

[ Name ]:
6-[[(1,1-Dimethylethoxy)carbonyl]amino]hexanoic acid 2,5-dioxo-1-pyrrolidinyl ester

[Synonym ]:
(2,5-dioxopyrrolidin-1-yl) 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
Boc-6-Ahx-OSu
6-(Boc-amino)caproic acid N-succinimidyl ester (6-(Boc-amino)hexanoic acid N-succinimidyl ester
6-[[(1,1-Dimethylethoxy)carbonyl]amino]hexanoic acid 2,5-dioxo-1-pyrrolidinyl ester

Biological Activity

[Description]:

6-(N-Boc)caproic acid NHS is a protein cross-linking agent.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Michael S. Bernatowicz, et al. A comparison of acid labile linkage agents for the synthesis of peptide C-terminal amides. Tetrahedron Letters, Volume 30, Issue 35, 1989, Pages 4645-4648.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Melting Point ]:
86-90ºC

[ Molecular Formula ]:
C₁₅H₂₄N₂O₆

[ Molecular Weight ]:
328.36100

[ Exact Mass ]:
328.16300

[ PSA ]:
102.01000

[ LogP ]:
2.00750

[ Index of Refraction ]:
1.507

[ Water Solubility ]:
Very slightly soluble (0.95 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R38

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Chromogenic and fluorogenic glycosylated and acetylglycosylated peptides as substrates for serine, thiol and aspartyl proteases.

J. Pept. Res. 53 , 109, (1999)

We synthesized short chromogenic peptidyl-Arg-p-nitroanilides containing either (Galbeta)Ser or (Glcalpha,beta)Tyr at P2 or P3 sites as well as O-acetylated sugar moieties and studied their hydrolysis...

An efficient stereoselective synthesis of 6-alpha-aminoestradiol: preparation of estradiol fluorescent probes.

Steroids 62 , 462, (1997)

6-Oxoestradiol (2) was protected as its bis[(2-trimethylsilylethoxy)methyl] ether (4) and converted to the corresponding oxime (4). The oxime (4) on reduction with zinc in ethanol afforded the bis-SEM...

Related Compounds

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