Methylene-bis(4-cyclohexylisocyanate)
Names
[ CAS No. ]:
5124-30-1
[ Name ]:
Methylene-bis(4-cyclohexylisocyanate)
[Synonym ]:
Methylene-bis(4-cyclohexylisocyanate)
4,4'-Methylenebis(cyclohexyl isocyanate)
Dicyclohexylmethane 4,4′-diisocyanate
MFCD00015405
Dicyclohexylmethane 4,4'-Diisocyanate
4,4-Methylenebis(Cyclohexyl Isocyanate)
EINECS 225-863-2
Chemical & Physical Properties
[ Density]:
1.066 g/mL at 25 °C(lit.)
[ Boiling Point ]:
168 °C / 1.5mmHg
[ Melting Point ]:
25°C
[ Molecular Formula ]:
C15H22N2O2
[ Molecular Weight ]:
262.34700
[ Flash Point ]:
211 ºC
[ Exact Mass ]:
262.16800
[ PSA ]:
58.86000
[ LogP ]:
3.16570
[ Index of Refraction ]:
n20/D 1.497(lit.)
[ Water Solubility ]:
Insoluble/Reactive
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NQ9250000
- CHEMICAL NAME :
- Isocyanic acid, methylenedi-4,1-cyclohexylene ester
- CAS REGISTRY NUMBER :
- 5124-30-1
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C15-H22-N2-O2
- MOLECULAR WEIGHT :
- 262.39
- WISWESSER LINE NOTATION :
- L6TJ ANCO D1- AL6TJ DNCO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530188
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9900 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Liver - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS000555173
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 ppm/5H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,998,1991
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle weakness
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555173
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 51 mg/m3/1H
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534736 *** REVIEWS *** ACGIH TLV-TWA 0.054 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-BELGIUM:TWA 0.005 ppm (0.054 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.005 ppm (0.054 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 ppm (0.11 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE-air:CL 0.01 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1655 No. of Facilities: 102 (estimated) No. of Industries: 6 No. of Occupations: 22 No. of Employees: 4022 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1175 No. of Facilities: 624 (estimated) No. of Industries: 16 No. of Occupations: 18 No. of Employees: 7764 (estimated) No. of Female Employees: 637 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H317-H319-H331-H334-H335
[ Precautionary Statements ]:
P261-P280-P284-P304 + P340 + P312-P342 + P311-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R23;R36/37/38;R42/43
[ Safety Phrases ]:
S26-S28-S38-S45-S1/2
[ RIDADR ]:
UN 2206 6.1/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
NQ9250000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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