Clanfenur

Names

[ Name ]:
Clanfenur

[Synonym ]:
1-(2-Dimethylaminoethyl)-piperazine
dimethyl(2-piperazinylethyl)amine
1-(2-N,N-dimethylamino-6-fluorobenzoyl)-3-(4-chlorophenyl)urea
N,N-Dimethyl-2-(piperazin-1-yl)ethanamine
N-(CH2)2NMe2-piperazine
4-(2-dimethylaminoethyl)piperazine
dimethyl(2-piperazin-1-yl-ethyl)amine
N-[[(4-chlorophenyl)amino]carbonyl]-2-(dimethylamino)-6-fluorobenzamide
1-(2-N,N-dimethyl)-ethylpiperazine

Biological Activity

[Description]:

Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. J D Jonkman-de Vries, et al. Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51(2):89-95.

Chemical & Physical Properties

[ Density]:
1.371g/cm3

[ Molecular Formula ]:
C₁₆H₁₅ClFN₃O₂

[ Molecular Weight ]:
335.76

[ Exact Mass ]:
335.08400

[ PSA ]:
61.44000

[ LogP ]:
3.97090

[ Index of Refraction ]:
1.64

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%