yamogenin

Names

[ CAS No. ]:
512-06-1

[ Name ]:
yamogenin

[Synonym ]:
Spirost-5-en-3-ol, (3β,25S)-
(3β,25S)-Spirost-5-en-3-ol
yamogenin

Biological Activity

[Description]:

Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> LXR

Research Areas >> Metabolic Disease

[Target]

IC50: TG accumulation; liver X receptor (LXR)[1]

[References]

[1]. Moriwaki S, et al. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.Biosci Biotechnol Biochem. 2014;78(7):1231-6.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₂O₃

[ Molecular Weight ]:
414.621

[ Flash Point ]:
272.6±30.1 °C

[ Exact Mass ]:
414.313385

[ PSA ]:
38.69000

[ LogP ]:
5.84

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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