3,4-Dichloro-isocoumarin

Names

[ CAS No. ]:
51050-59-0

[ Name ]:
3,4-Dichloro-isocoumarin

[Synonym ]:
3,4-dichloroisochromen-1-one
3,4-Dichloro-2-benzopyran-1-one 3,4-DCI
MFCD00036960

Biological Activity

[Description]:

3,4-Dichloroisocoumarin is a potent serine-protease inhibitor that inhibits chymotrypsin-like activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Metabolic Disease

[References]

[1]. H Djaballah, et al. Use of serine-protease inhibitors as probes for the different proteolytic activities of the rat liver multicatalytic proteinase complex. Eur J Biochem. 1992 Oct 15;209(2):629-34.

Chemical & Physical Properties

[ Density]:
1.53 g/cm3

[ Boiling Point ]:
304.7ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₄Cl₂O₂

[ Molecular Weight ]:
215.03300

[ Flash Point ]:
136.6ºC

[ Exact Mass ]:
213.95900

[ PSA ]:
30.21000

[ LogP ]:
3.09980

[ Index of Refraction ]:
1.627

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

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