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Verapamil EP Impurity C hydrochloride

Names

[ CAS No. ]:
51012-67-0

[ Name ]:
Verapamil EP Impurity C hydrochloride

[Synonym ]:
2-(3,4-Dimethoxyphenyl)-N,N-dimethylethanamine hydrochloride (1:1)
Benzeneethanamine, 3,4-dimethoxy-N,N-dimethyl-, hydrochloride (1:1)

Biological Activity

[Description]:

NSC-609249 hydrochloride is an impurity of Verapamil (HY-14275). Verapamil is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Research Areas >> Metabolic Disease

[References]

[1]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746.

[2]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H20ClNO2

[ Molecular Weight ]:
245.746

[ Exact Mass ]:
245.118256

Related Compounds