4'-Methoxyacetanilide

Names

[ CAS No. ]:
51-66-1

[ Name ]:
4'-Methoxyacetanilide

[Synonym ]:
Acetamide, N-(4-methoxyphenyl)-
methyl ether of paracetamol
4-(Acetylamino)anisole
p-Acetanisidine
N-Ac-4-methoxyaniline
acetaniside
4'-Methoxyacetanilide
MFCD00014963
2-methoxy-5-acetylamino-benzene
4-Acetaniside
4-acetylamino-anisole
N-(4-Methoxyphenyl)acetamide
Metacetin
P-ACETANISIDIDE
AURORA KA-3672
EINECS 200-114-2
METHACETIN
4-ACETANISIDINE
Acetanilide, 4'-methoxy-
N-(p-Methoxyphenyl)acetamide
p-acetaniside
4-ACETANISIDIDE
para-methoxyacetanilide

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
345.5±25.0 °C at 760 mmHg

[ Melting Point ]:
128-130 °C(lit.)

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.189

[ Flash Point ]:
162.8±23.2 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
38.33000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.558

[ Water Solubility ]:
0.42 g/100 mL (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE8290000

CHEMICAL NAME :: p-Acetanisidide

CAS REGISTRY NUMBER :: 51-66-1

BEILSTEIN REFERENCE NO. :: 0387887

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: 1VMR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,20,1971

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC) Volume(issue)/page/year: 271,71,1941

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S36-S37/39-S26

[ WGK Germany ]:
1

[ RTECS ]:
AE8290000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%