Dextrothyroxine

Names

[ CAS No. ]:
51-49-0

[ Name ]:
Dextrothyroxine

[Synonym ]:
EINECS 200-102-7
(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
(R)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid
D-Thyroxine
MFCD00063056
Choloxin
Thyroxine
3,3′,5,5″-Tetraiodo-D-thyronine
D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine

Biological Activity

[Description]:

D-Thyroxine (D-T4) is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Bantle JP, et, al. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. Am J Med. 1984 Sep;77(3):475-81.

[2]. Gless KH, et, al. Influence of D-thyroxine on plasma thyroid hormone levels and TSH secretion. Horm Metab Res. 1977 Jan;9(1):69-73.

Chemical & Physical Properties

[ Density]:
2.6±0.1 g/cm3

[ Boiling Point ]:
576.3±50.0 °C at 760 mmHg

[ Melting Point ]:
225ºC

[ Molecular Formula ]:
C₁₅H₁₁I₄NO₄

[ Molecular Weight ]:
776.870

[ Flash Point ]:
302.3±30.1 °C

[ Exact Mass ]:
776.686646

[ PSA ]:
92.78000

[ LogP ]:
5.93

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.795

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.

J. Med. Chem. 50 , 5589-99, (2007)

Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. In this study, we explore the potential of biphenyl ethers (BPE), which are shown to...

Maintenance of brain thyroid hormone level during peripheral hypothyroid condition in adult rat.

Life Sci. 79(15) , 1450-5, (2006)

Thyroid hormones are essential for normal functioning of adult mammalian brain. The present investigation deals with the understanding of the time course of thyroid hormone homeostasis in adult rat br...

Dextrothyroxine in the treatment of generalized thyroid hormone resistance in a boy homozygous for a defect in the T3 receptor.

Thyroid 2(1) , 15-9, (1992)

The dextroisomer of thyroxine (D-T4) has been shown to have suppressive effects on pituitary TSH secretion in euthyroid individuals and patients with mild thyroid hormone resistance. We treated a 3-ye...

Related Compounds

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