Tiratricol

Names

[ CAS No. ]:
51-24-1

[ Name ]:
Tiratricol

[Synonym ]:
triiodothyroacetic acid
Tiratricol,3,3',5-triiodothyroacetic acid
3,5,3'-triiodothyroacetic acid
Benzeneacetic acid, 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-
3,3',5-TRIIODOTHYROACETIC ACID
3,3',5-Triiodo-4-(4-hydroxyphenoxy)phenylacetic Acid
Triac
3,5-Diiodo-4-(3-iodo-4-hydroxyphenoxy)phenylacetic Acid
[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
Tiratricol

Biological Activity

[Description]:

Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.

[Related Catalog]:

Signaling Pathways >> Others >> Thyroid Hormone Receptor

Research Areas >> Endocrinology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.5±0.1 g/cm3

[ Boiling Point ]:
531.6±50.0 °C at 760 mmHg

[ Melting Point ]:
181.5ºC

[ Molecular Formula ]:
C₁₄H₉I₃O₄

[ Molecular Weight ]:
621.932

[ Flash Point ]:
275.3±30.1 °C

[ Exact Mass ]:
621.763489

[ PSA ]:
66.76000

[ LogP ]:
5.47

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.767

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

A surface on the androgen receptor that allosterically regulates coactivator binding.

Proc. Natl. Acad. Sci. U. S. A. 104 , 16074-9, (2007)

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that medi...

Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

J. Med. Chem. 54 , 8563-73, (2011)

The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of actio...