Verproside

Names

[ Name ]:
Verproside

Biological Activity

[Description]:

Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Infection

Research Areas >> Others

Signaling Pathways >> Apoptosis >> TNF Receptor

[Target]

NF-κB

TNF-α

IKK

[In Vitro]

Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1]. Western Blot Analysis[1] Cell Line: NCI-H292 cells Concentration: 2.5, 5, 10, 20 μM Incubation Time: 2 hours Result: Resulted in markedly reduced phosphorylation levels of IKKα/β, IκBα, and TAK1.

[In Vivo]

Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2]. Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2] Dosage: 30 mg/kg Administration: Intragastrically; 48 hours Result: Reduced significantly the immunoglobulin E (IgE) levels.

[References]

[1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75.

[2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10.

Chemical & Physical Properties

[ Density]:
1.75±0.1 g/cm3(Predicted)

[ Boiling Point ]:
822.9±65.0 °C(Predicted)

[ Molecular Formula ]:
C₂₂H₂₆O₁₃

[ Molecular Weight ]:
498.43

[ Storage condition ]:
?20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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