Pentacosylic acid

Names

[ CAS No. ]:
506-38-7

[ Name ]:
Pentacosylic acid

[Synonym ]:
Pentacosylic acid
n-Pentacosanoic acid
Pentacosanoic acid
EINECS 208-036-0
MFCD00020551

Biological Activity

[Description]:

Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate[1].

[Related Catalog]:

Research Areas >> Others

[In Vivo]

The degree of demyelination in adrenoleukodystrophy is related to the Pentacosanoic to Docosanoic acid ratios (C25:0/C22:0 and C26:0/C22:0). Mainly saturated fatty acids of the middle class components (C24:0, C25:0 and C26:0) are found in severely affected areas where the active process is complete. Because a region of high long chain fatty acid content, lacking histopathological change, is detected[1]. The area with myelin destruction with axonal preservation is generally most prominent in the frontal edge of the lesion. A bell-shaped distribution of very long chain fatty acids, esterified to cholesterol, are detectable, with the mid-point being formed by Pentacosanoic (C25 : 0) and Hexacosanoic (C26 : 0) acids[1].

[References]

[1]. Reinecke CJ, et al. The correlation between biochemical and histopathological findings in adrenoleukodystrophy. J Neurol Sci. 1985 Aug;70(1):21-38.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
412.4±8.0 °C at 760 mmHg

[ Melting Point ]:
83 °C

[ Molecular Formula ]:
C₂₅H₅₀O₂

[ Molecular Weight ]:
382.663

[ Flash Point ]:
185.0±13.3 °C

[ Exact Mass ]:
382.381073

[ PSA ]:
37.30000

[ LogP ]:
11.94

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2915900090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Related Compounds

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