EDANS

Names

[ Name ]:
EDANS

[Synonym ]:
5-(2-Aminoethylamino)-1-naphthalenesulfonic acid
1,5-EDANS (N-(Aminoethyl)-5-naphthylamine-1-sulfonic acid
5-(2-aminoethylamino)naphthalene-1-sulfonic acid
MFCD00066932
EINECS 256-575-5

Biological Activity

[Description]:

EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

The peptide sequence of EDANS is derived from a natural processing site for HIV-1 PR[1]. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that was linearly related to the extent of substrate hydrolysis[1].

[References]

[1]. E D Matayoshi, et al. Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer. Science. 1990 Feb 23;247(4945):954-8.

Chemical & Physical Properties

[ Density]:
1.432 g/cm3

[ Melting Point ]:
>350°C

[ Molecular Formula ]:
C₁₂H₁₄N₂O₃S

[ Molecular Weight ]:
266.31600

[ Exact Mass ]:
266.07300

[ PSA ]:
100.80000

[ LogP ]:
3.31120

[ Index of Refraction ]:
1.691

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38-43

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ WGK Germany ]:
3

[ HS Code ]:
2921590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%