CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC
Names
[ CAS No. ]:
50372-80-0
[ Name ]:
CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC
[Synonym ]:
8-Azabicyclo(3.2.1)octane-2-carboxylic acid,8-methyl-3-phenyl-,methyl ester,(1R-(exo,exo))
WIN35,065-2
methyl <1R-(exo,exo)>-8-methyl-3-phenyl-8-azabicyclo<3.2.1>octane-2-carboxylate
[1R-(exo,exo)]-8-Methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester
Chemical & Physical Properties
[ Density]:
1.099g/cm3
[ Boiling Point ]:
350.2ºC at 760 mmHg
[ Molecular Formula ]:
C20H27NO8
[ Molecular Weight ]:
409.43000
[ Flash Point ]:
121.3ºC
[ Exact Mass ]:
409.17400
[ PSA ]:
144.60000
[ LogP ]:
0.24120
[ Index of Refraction ]:
1.54
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CL5603110
- CHEMICAL NAME :
- 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 8-methyl-3-phenyl-, methyl ester, (1R-(exo,exo))-
- CAS REGISTRY NUMBER :
- 50372-80-0
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H21-N-O2
- MOLECULAR WEIGHT :
- 259.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 16,1260,1973
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2933990090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Eur. J. Pharmacol. 184(2-3) , 329-32, (1990)
Two potent cocaine analogs have been developed that have the highest known affinities for the cocaine binding site in rat striatum. Both 3 beta-(4-chlorophenyl)- (RTI-COC-31) and 3 beta-(4-methylpheny...
Saturable (3H)cocaine binding in central nervous system of mouse.Life Sci. 27(12) , 1055-62, (1980)
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
J. Med. Chem. 40(8) , 1247-51, (1997)
2beta,3beta-Diphenyl-(5), 2alpha,3alpha-diphenyl-(6), and 2alpha,3beta-diphenyltropane (3) as well as 2,3-diphenyltrop-2-ene (4) were prepared in racemic form and assayed for inhibition of radioligand...