Rosuvastatin Lactone

Names

[ Name ]:
Rosuvastatin Lactone

[Synonym ]:
Methanesulfonamide, N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methyl-
RosuvastatinLactone
(3R,5R)-ROSUVASTATIN LACTONE
Rosuvastatin lactone
N-[4-(4-Fluorophenyl)-5-{(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]vinyl}-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide
ROSUVASTATIN-5S-LACTONE

Biological Activity

[Description]:

Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Lee HB, et al. Occurrence and fate of rosuvastatin, rosuvastatin lactone, and atorvastatin in Canadian sewage and surface water samples. Chemosphere. 2009 Nov;77(10):1285-91.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
695.0±65.0 °C at 760 mmHg

[ Melting Point ]:
131℃

[ Molecular Formula ]:
C₂₂H₂₆FN₃O₅S

[ Molecular Weight ]:
463.522

[ Flash Point ]:
374.1±34.3 °C

[ Exact Mass ]:
463.157715

[ PSA ]:
118.07000

[ LogP ]:
0.42

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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