Fluoroacetonitrile
Names
[ CAS No. ]:
503-20-8
[ Name ]:
Fluoroacetonitrile
[Synonym ]:
Acetonitrile, 2-fluoro-
MFCD00009969
Fluoroacetonitrile
2-fluoroacetonitrile
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
79.5±0.0 °C at 760 mmHg
[ Melting Point ]:
-13 °C
[ Molecular Formula ]:
C2H2FN
[ Molecular Weight ]:
59.042
[ Flash Point ]:
-13.9±0.0 °C
[ Exact Mass ]:
59.017128
[ PSA ]:
23.79000
[ LogP ]:
-0.39
[ Vapour Pressure ]:
88.8±0.1 mmHg at 25°C
[ Index of Refraction ]:
1.303
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM0175000
- CHEMICAL NAME :
- Acetonitrile, fluoro-
- CAS REGISTRY NUMBER :
- 503-20-8
- BEILSTEIN REFERENCE NO. :
- 1697891
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C2-H2-F-N
- MOLECULAR WEIGHT :
- 59.05
- WISWESSER LINE NOTATION :
- NC1F
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 78,3484,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
Safety Information
[ Symbol ]:
GHS02, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H315-H319-H335
[ Precautionary Statements ]:
P210-P261-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable;T:Toxic;
[ Risk Phrases ]:
R11;R23/24/25;R36/37/38
[ Safety Phrases ]:
S16-S26-S27-S36/37/39-S45
[ RIDADR ]:
UN 3273
[ RTECS ]:
AM0175000
[ Packaging Group ]:
II
[ Hazard Class ]:
3.1
[ HS Code ]:
2926909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Tetrahedron Lett. 31(2) , 179-82, (1990)
Preparative flow techniques. 2. Grignard addition reaction on fluoroaceto-nitrile: Synthesis of 2-amino-2-fluoromethyl-3-pentenenitrile. Gerhart F, et al.
J. Fluor. Chem. 50(2) , 243-49, (1990)