TIE-2/VEGFR-2 kinase-IN-2

Names

[ Name ]:
TIE-2/VEGFR-2 kinase-IN-2

Biological Activity

[Description]:

TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2

Tie-2

[References]

[1]. Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₃F₄N₅O₂

[ Molecular Weight ]:
431.34

Related Compounds

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