Rilonacept

Names

[ Name ]:
Rilonacept

Biological Activity

[Description]:

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[Target]

IL-1

[In Vitro]

Rilonacept 通过充当结合 IL-1β 并阻止其与细胞表面受体相互作用的可溶性诱饵受体来阻断 IL-1α 信号传导，从而减少炎症过程[1]。

[References]

[1]. Kapur S, et, al. Rilonacept (arcalyst), an interleukin-1 trap for the treatment of cryopyrin-associated periodic syndromes. P T. 2009 Mar;34(3):138-41.

Chemical & Physical Properties

No Any Chemical & Physical Properties