Rhododendrol

Names

[ CAS No. ]:
501-96-2

[ Name ]:
Rhododendrol

[Synonym ]:
4-[(3R)-3-Hydroxybutyl]phenol
Benzenepropanol, 4-hydroxy-α-methyl-
4-(3-Hydroxybutyl)phenol
4-(p-Hydroxyphenyl)-2-butanol
Benzenepropanol, 4-hydroxy-α-methyl-, (R)-
Benzenepropanol, 4-hydroxy-α-methyl-, (αR)-
2-Butanol, 4-(p-hydroxyphenyl)-
UNII:12QWN45UL0
Rhododendrol
(-)-Rhododendrol

Biological Activity

[Description]:

Rhododendrol can induce leukoderma. Rhododendrol induces generation of hydroxyl radicals and melanocyte cytotoxicity by increasing glutathione levels. Rhododendrol is a phenolic compound that can be isolated from plants such as Acer nikoense and Betula platyphylla[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Gabe Y, et al. Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma. J Dermatol Sci. 2018 Sep;91(3):311-316.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
315.4±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄O₂

[ Molecular Weight ]:
166.22

[ Flash Point ]:
153.4±15.5 °C

[ Exact Mass ]:
166.099380

[ PSA ]:
40.46000

[ LogP ]:
1.49

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma.

Dermatology 232 , 44-9, (2016)

Rhododendrol, a phenolic compound contained in lightening/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affect...

Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism.

Pigment Cell Melanoma Res. 27(5) , 754-63, (2014)

Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical cont...

Related Compounds

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