Chlorazanil

Names

[ CAS No. ]:
500-42-5

[ Name ]:
Chlorazanil

[Synonym ]:
N2-(4-Chlor-phenyl)-[1,3,5]triazin-2,4-diyldiamin
Chlorazinil
Neo-Urofort
Chlorazanil
Daquin
Orpizin
Triazurol
N2-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diyldiamine
Chloroazinal
Neurofort
Diurazine
N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine
Riker 545

Biological Activity

[Description]:

Chlorazanil is a triazine derivative and also a new nonmercurial diuretic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Thevis M, et al. Formation of the diuretic chlorazanil from the antimalarial drug proguanil--implications for sports drug testing. J Pharm Biomed Anal. 2015 Nov 10;115:208-13.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.483g/cm3

[ Boiling Point ]:
457.2ºC at 760mmHg

[ Molecular Formula ]:
C₉H₈ClN₅

[ Molecular Weight ]:
221.64600

[ Flash Point ]:
230.3ºC

[ Exact Mass ]:
221.04700

[ PSA ]:
76.72000

[ LogP ]:
2.50500

[ Index of Refraction ]:
1.72

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY3150500

CHEMICAL NAME :: s-Triazine, 2-amino-4-(p-chloroanilino)-

CAS REGISTRY NUMBER :: 500-42-5

BEILSTEIN REFERENCE NO. :: 0016503

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H8-Cl-N5

MOLECULAR WEIGHT :: 221.67

WISWESSER LINE NOTATION :: T6N CN ENJ BZ DMR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 79,5064,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,350,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,225,1964

Safety Information

[ HS Code ]:
2933699090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933699090

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%