Benzyl-PEG1-Tos

Names

[ Name ]:
Benzyl-PEG1-Tos

[Synonym ]:
1-benzyloxy-2-tosyloxyethane
2-benzyloxyethyl p-toluenesulfonate
2-Benzyl-Oxyethyl Chloroformate
1-O-benzyl-2-O-p-toluenesulfonyl ethylene glycol

Biological Activity

[Description]:

Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈O₄S

[ Molecular Weight ]:
306.37700

[ Exact Mass ]:
306.09300

[ PSA ]:
60.98000

[ LogP ]:
3.99790

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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