Dobutamine hydrochloride

Names

[ Name ]:
Dobutamine hydrochloride

[Synonym ]:
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-b-phenylethylamine Hydrochloride
4-(2-{[4-(4-Hydroxyphenyl)-2-butanyl]amino}ethyl)-1,2-benzenediol hydrochloride (1:1)
EINECS 256-464-1
1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (1:1)
Dobutamine hydrochloride
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine Hydrochloride
1,2-benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride
(±)-4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol hydrochloride
4-(2-{[4-(4-Hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol hydrochloride (1:1)
4-(2-{[3-(4-hydroxyphényl)-1-méthylpropyl]amino}éthyl)benzène-1,2-diol chlorhydrate
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzol-1,2-diolhydrochlorid
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol hydrochloride
rac Dobutamine Hydrochloride
(±)-4-[2-[[3-(p-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]pyrocatechol Hydrochloride
MFCD00153795
Dobutamine (hydrochloride)

Biological Activity

[Description]:

Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Cardiovascular Disease

[References]

[1]. Dobutamine, From wikipedia

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
527.7ºC at 760mmHg

[ Melting Point ]:
184-186ºC(lit.)

[ Molecular Formula ]:
C₁₈H₂₄ClNO₃

[ Molecular Weight ]:
337.841

[ Flash Point ]:
169.8ºC

[ Exact Mass ]:
337.144470

[ PSA ]:
72.72000

[ LogP ]:
4.14970

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H361

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R63

[ Safety Phrases ]:
S22-S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Preventive and therapeutic effects of a beta adrenoreceptor agonist, dobutamine, in carrageenan-induced inflammatory nociception in rats.

Inflammation 37(5) , 1814-25, (2014)

We hypothesized that locally administrated β-adrenoreceptor agonist can modulate the inflammatory nociceptive parameters in carrageenan (CG)-induced peripheral inflammatory pain. This study was theref...

Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.

Am. J. Vet. Res. 75(7) , 668-79, (2014)

To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses.9 Thoroughbred or Standardbred mares (mean ± SD age, 5.22 ± 1.09 years [range, 2 to 12 years]; mean body w...

Dobutamine stress MRI for the assessment of coronary artery disease: initial clinical experience in Israel.

Isr. Med. Assoc. J. 15(5) , 205-9, (2013)

Over the past few years dobutamine stress magnetic resonance (DSMR) has proven its efficacy as an integral part of the diagnosis of coronary artery disease (CAD).To present the feasibility and safety ...