5-hydroxyuracil
Names
[ CAS No. ]:
496-76-4
[ Name ]:
5-hydroxyuracil
[Synonym ]:
Pyrimidinetriol
2,4,6-ThihydroxypyriMidine
pyrimidine-2,4,5-triol
Isobarbitursaeure
2,4,5-pyrimidinetriol
2,4(1H,3H)-Pyrimidinedione, 5-hydroxy-
Isobarbituric Acid
2,4,5-Trihydroxypyrimidine,5-Hydroxyuracil,Isobarbituric acid
5-hydroxyuracil
2,4,5-Trihydroxypyrimidine
Fluorouracil impurity B
5-hydroxyisouracil
5-Hydroxypyrimidine-2,4(1H,3H)-dione
5-Hydroxy-2,4(1H,3H)-pyrimidinedione
TRIFLUOROACETIC ACID REAGENTPLUS
EINECS 207-829-9
MFCD00082987
Isobarbituric acid (VAN) (8CI)
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
534.5±53.0 °C at 760 mmHg
[ Melting Point ]:
300ºC
[ Molecular Formula ]:
C4H4N2O3
[ Molecular Weight ]:
128.086
[ Flash Point ]:
277.0±30.9 °C
[ Exact Mass ]:
128.022186
[ PSA ]:
85.95000
[ LogP ]:
-2.10
[ Appearance of Characters ]:
crystalline | light yellow
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.719
[ Water Solubility ]:
Soluble in DMSO (Sparingly), Methanol (Sparingly).
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
J. Pharm. Biomed. Anal. 98 , 446-62, (2014)
The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in the situation of commercial formulations for clinical use, namely FU dissolved in sodium hydroxide (NaOH) ...
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.Nucleic Acids Res. 32(17) , 5291-302, (2004)
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-h...
Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals.Org. Lett. 12(18) , 4130-3, (2010)
Addition of millimolar amounts of a weak base (pyridines) dramatically accelerates the reaction with peroxyl radicals of two biologically relevant uracil derivatives, 5-hydroxyuracil (HU) and 5-hydrox...