(R)-Pantetheine

Names

[ CAS No. ]:
496-65-1

[ Name ]:
(R)-Pantetheine

[Synonym ]:
(2R)-2,4-Dihydroxy-N-[2-[(2-mercaptoethyl)carbamoyl]ethyl]-3,3-dimethylbutyramide
Lactobacillusbulgaricusfactor
pantethine,Bis(N-pantothenylamidoethyl) disulfide
D-pantothenic acid-(2-mercapto-ethylamide)
D-N-pantothenylamidoethyl mercaptan
2,4-dihydroxy-3,3-dimethyl-N-[2-(2-sulfanylethylcarbamoyl)ethyl]butanamide
(R)-2,4-Dihydroxy-N-[3-[(2-mercaptoethyl)amino]-3-oxopropyl]-3,3-dimethylbutanamide
(R)-2,4-dihydroxy-N-[3-[(2-mercaptoethyl)amino]-3-oxopropyl]-3,3-dimethylbutyramide
Pantetheine

Biological Activity

[Description]:

(R)-Pantetheine is the biosynthetic precursor to CoA.(R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Rothmann M, et al. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24;135(16):5962-5.

Chemical & Physical Properties

[ Density]:
1.202g/cm3

[ Boiling Point ]:
635ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₂₂N₂O₄S

[ Molecular Weight ]:
278.36800

[ Flash Point ]:
337.8ºC

[ Exact Mass ]:
278.13000

[ PSA ]:
137.46000

[ Vapour Pressure ]:
8.53E-19mmHg at 25°C

[ Index of Refraction ]:
1.526

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES4316750

CHEMICAL NAME :: Butyramide, 2,4-dihydroxy-N-(2-((2-mercaptoethyl)carbamoyl)ethyl) -3,3-dimethyl-

CAS REGISTRY NUMBER :: 496-65-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H22-N2-O4-S

MOLECULAR WEIGHT :: 278.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954- Volume(issue)/page/year: 7,13,1957

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
45

[ RIDADR ]:
UN 2811 6.1 / PGIII