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Nodakenin

Names

[ CAS No. ]:
495-31-8

[ Name ]:
Nodakenin

[Synonym ]:
2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)-2-propanyl β-D-glucopyranoside
2-(7-Oxo-2,3-dihydro-7H-furo[3,2-g]chromen-3-yl)propan-2-yl β-D-glucopyranoside
2-[1-(b-D-Glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 3-[1-(β-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-
Nodakenetin Glucoside

Biological Activity

[Description]:

Nodakenin is a major coumarin glucoside in the root of Peucedanum decursivum Maxim. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC50 of 84.7 μM[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Kim DH, et al. Nodakenin, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci. 2007 May 1;80(21):1944-50.

[2]. Xiong Y, et al. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):341-8.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
635.4±55.0 °C at 760 mmHg

[ Melting Point ]:
melting at 216°

[ Molecular Formula ]:
C20H24O9

[ Molecular Weight ]:
408.399

[ Flash Point ]:
225.4±25.0 °C

[ Exact Mass ]:
408.142029

[ PSA ]:
138.82000

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.651

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Related Compounds