7-aminonitrazepam
Names
[ CAS No. ]:
4928-02-3
[ Name ]:
7-aminonitrazepam
[Synonym ]:
7-Amino-1,2-dihydro-3H-1,4-benzodiazepin-2-one
7-Amino-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin
7-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Amino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo<e>-1,4-diazepin
7-amino-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
7-Amino Nitrazepam
Ro 5-3072
7-Amino-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one,7-amino-1,3-dihydro-5-phenyl
7-amino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepinon-(2)
7-Amino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Chemical & Physical Properties
[ Density]:
1.3g/cm3
[ Boiling Point ]:
495.8ºC at 760 mmHg
[ Melting Point ]:
242-244ºC
[ Molecular Formula ]:
C15H13N3O
[ Molecular Weight ]:
251.28300
[ Flash Point ]:
253.6ºC
[ Exact Mass ]:
251.10600
[ PSA ]:
67.48000
[ LogP ]:
2.21310
[ Index of Refraction ]:
1.683
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE9750000
- CHEMICAL NAME :
- 2H-1,4-Benzodiazepin-2-one, 7-amino-1,3-dihydro-5-phenyl-
- CAS REGISTRY NUMBER :
- 4928-02-3
- BEILSTEIN REFERENCE NO. :
- 0535813
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H13-N3-O
- MOLECULAR WEIGHT :
- 251.31
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,209,1991
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302 + H332-H319
[ Precautionary Statements ]:
P210-P305 + P351 + P338
[ Hazard Codes ]:
F,Xn
[ Risk Phrases ]:
11-20/21/22-36
[ Safety Phrases ]:
16-36/37
[ RIDADR ]:
UN 1648 3 / PGII
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Ann. Clin. Biochem. 47(Pt 2) , 111-7, (2010)
Liquid chromatography linked to tandem mass spectrometry (LC/MS/MS) provides the ability to identify a range of benzodiazepines in accordance with European Union criteria and is an attractive method f...
A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry.Biomed. Chromatogr. 23(7) , 740-4, (2009)
A highly sensitive method has been developed for the determination of urinary 7-aminonitrazepam (7-ANZP), the major metabolite of nitrazepam, using high-performance electrospray liquid chromatography ...
Determination of nitrazepam and its main metabolites in urine by thin-layer chromatography and direct densitometry.J. Chromatogr. A. 339(1) , 163-9, (1985)
A method for the direct quantitative densitometry of nitrazepam and its main metabolites (7-aminonitrazepam, 7-acetamidonitrazepam and 2-amino-5-nitrobenzophenone) in urine was developed. The unchange...