PHA690509

Names

[ Name ]:
PHA690509

[Synonym ]:
(2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno-[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
NOP-1A
(2S)-2-[4-(acetylamino)phenyl]-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide
Benzeneacetamide, 4-(acetylamino)-α-methyl-N-[5-(1-methylethyl)-2-thiazolyl]-, (αS)-
(2S)-2-[(3,6-diethylpyrazin-2-yl)amino]butan-1-ol

Biological Activity

[Description]:

PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. Devillers J. Repurposing drugs for use against Zika virus infection. SAR QSAR Environ Res. 2018 Feb;29(2):103-115.

[2]. Alam A, et al. Recent trends in ZikV research: A step away from cure. Biomed Pharmacother. 2017 Jul;91:1152-1159.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₂₁N₃O₂S

[ Molecular Weight ]:
331.432

[ Exact Mass ]:
331.135437

[ PSA ]:
106.31000

[ LogP ]:
3.09

[ Index of Refraction ]:
1.629

Synthetic Route

Click to get detail synthetic route

Related Compounds

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