Emodinanthrone

Names

[ CAS No. ]:
491-60-1

[ Name ]:
Emodinanthrone

[Synonym ]:
1,3,8-Trihydroxy-6-methyl-anthron
6-methyl-1,3,8-trihydroxy-10H-anthracene-9-one
Emodinanthrone
1,3,8-trihydroxy-6-methyl-anthrone

Biological Activity

[Description]:

Emodinanthrone, an anthraquinone, is a sprecursor of Emodin with antibiotic activity. Emodinanthrone inhibits respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli[1][2][3].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Emodinanthrone is used as an alternative substrate for the AknX oxygenase assay[1].

[References]

[1]. Jin-Young Chung, et al. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22.

[2]. T Ubbink-Kok, et al. Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli. Antimicrob Agents Chemother. 1986 Jul;30(1):147-51.

[3]. M K Wang, et al. Triterpenoid saponins from Berneuxia thebetica. Phytochemistry. 1998 Aug;48(8):1411-4.

Chemical & Physical Properties

[ Density]:
1.471 g/cm3

[ Boiling Point ]:
556.2ºC at 760 mmHg

[ Melting Point ]:
254-258 °C(dec.)

[ Molecular Formula ]:
C₁₅H₁₂O₄

[ Molecular Weight ]:
256.25300

[ Exact Mass ]:
256.07400

[ PSA ]:
77.76000

[ LogP ]:
2.24700

[ Vapour Pressure ]:
5.6E-13mmHg at 25°C

[ Index of Refraction ]:
1.723

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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