MAC13772

Names

[ Name ]:
MAC13772

[Synonym ]:
2-[(2-Nitrophenyl)thio]acetic Acid Hydrazide
2-(2-Nitro-phenylmercapto)-essigsaeure-hydrazid
2-(2-nitrophenylthio)acetohydrazide
2-[(2-nitrophenyl)thio]ethanohydrazide

Biological Activity

[Description]:

MAC13772 is a potent inhibitor of the enzyme BioA (IC50=250 nM), the antepenultimate step in biotin biosynthesis. MAC13772 is a novel antibacterial compound[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 250 nM (BioA)[1]

[References]

[1]. Zlitni S, et al. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol. 2013 Dec;9(12):796-804.

Chemical & Physical Properties

[ Density]:
1.44 g/cm3

[ Boiling Point ]:
461ºC at 760mmHg

[ Molecular Formula ]:
C₈H₉N₃O₃S

[ Molecular Weight ]:
227.24000

[ Flash Point ]:
232.6ºC

[ Exact Mass ]:
227.03600

[ PSA ]:
126.24000

[ LogP ]:
2.29120

[ Index of Refraction ]:
1.649

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.