Elemicin

Names

[ CAS No. ]:
487-11-6

[ Name ]:
Elemicin

[Synonym ]:
1,2,3-trimethoxy-5-prop-2-enylbenzene

Biological Activity

[Description]:

Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)

Research Areas >> Infection

[Target]

SCD1[1]

[References]

[1]. Yang XN, et al. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. Chem Res Toxicol. 2019 Sep 10.

Chemical & Physical Properties

[ Density]:
1.011 g/cm3

[ Boiling Point ]:
279.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆O₃

[ Molecular Weight ]:
208.25400

[ Flash Point ]:
92.6ºC

[ Exact Mass ]:
208.11000

[ PSA ]:
27.69000

[ LogP ]:
2.44090

[ Vapour Pressure ]:
0.00666mmHg at 25°C

[ Index of Refraction ]:
1.496

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY2801000

CHEMICAL NAME :: Benzene, 5-allyl-1,2,3-trimethoxy-

CAS REGISTRY NUMBER :: 487-11-6

BEILSTEIN REFERENCE NO. :: 1912664

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H16-O3

MOLECULAR WEIGHT :: 208.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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