Sphondin

Names

[ CAS No. ]:
483-66-9

[ Name ]:
Sphondin

[Synonym ]:
6-Methoxy-2H-furo[2,3-h]chromen-2-one
Sfondin
6-Methoxyfuro[2,3-h]chromen-2-one
2H-Furo[2,3-h]-1-benzopyran-2-one, 6-methoxy-
6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one
Sphondin
6-Methoxy-furano-<2',3'-7,8>cumarin,Sphondin

Biological Activity

[Description]:

Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2

[In Vitro]

Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].

[References]

[1]. Ling Ling Yang, et al. Effects of Sphondin, Isolated From Heracleum Laciniatum, on IL-1beta-induced cyclooxygenase-2 Expression in Human Pulmonary Epithelial Cells. Life Sci. 2002 Nov 29;72(2):199-213.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
413.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₈O₄

[ Molecular Weight ]:
216.189

[ Flash Point ]:
203.6±28.7 °C

[ Exact Mass ]:
216.042252

[ PSA ]:
52.58000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.635

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.