fervenulin

Names

[ CAS No. ]:
483-57-8

[ Name ]:
fervenulin

[Synonym ]:
6,8-Dimethyl-8H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion
6.8-Dimethyl-5.7-dioxo-5.6.7.8-tetrahydro-pyrimido<5.4-e>-as-triazin
Fervenuline
6,8-dimethyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
Kc 1017
Compound 7215
U-7118
Planomycin
Pulanomycin
Phervenulin

Biological Activity

[Description]:

Fervenulin, isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021, has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Nematicidal[1]

[In Vitro]

Fervenulin shows a broad range of biological activities, e.g., in vitro antibacterial, antifungal, antiparasitic, and antitumor properties. Fervenulin shows killing effect on second-stage nematode juveniles of M. incognita up to 100% after incubation for 96 h at the concentration of 250 μg/mL[1].

[References]

[1]. Ruanpanun P, et al. Nematicidal activity of Fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita. World J Microbiol Biotechnol. 2011 Jun;27(6):1373-80.

Chemical & Physical Properties

[ Density]:
1.474g/cm3

[ Boiling Point ]:
417.2ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₇N₅O₂

[ Molecular Weight ]:
193.16300

[ Flash Point ]:
206.1ºC

[ Exact Mass ]:
193.06000

[ PSA ]:
82.67000

[ Vapour Pressure ]:
3.61E-07mmHg at 25°C

[ Index of Refraction ]:
1.601

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7900000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-

CAS REGISTRY NUMBER :: 483-57-8

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,199,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,518,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 11200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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