Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fervenulin
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: FERVENULIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

483-57-8

483-57-8 structure

483-57-8 structure

Name: fervenulin
Chemical Name: fervenulin
CAS Number: 483-57-8
Molecular Formula: C₇H₇N₅O₂
Molecular Weight: 193.16300
Catalog: Research Areas Infection
Create Date: 2016-09-09 01:44:30
Modify Date: 2025-08-25 11:21:00
Fervenulin, isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021, has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively[1].

Name	fervenulin
Synonyms	6,8-Dimethyl-8H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion 6.8-Dimethyl-5.7-dioxo-5.6.7.8-tetrahydro-pyrimido<5.4-e>-as-triazin Fervenuline 6,8-dimethyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione Kc 1017 Compound 7215 U-7118 Planomycin Pulanomycin Phervenulin

Description	Fervenulin, isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021, has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively[1].
Related Catalog	Research Areas >> Infection
Target	Nematicidal[1]
In Vitro	Fervenulin shows a broad range of biological activities, e.g., in vitro antibacterial, antifungal, antiparasitic, and antitumor properties. Fervenulin shows killing effect on second-stage nematode juveniles of M. incognita up to 100% after incubation for 96 h at the concentration of 250 μg/mL[1].
References	[1]. Ruanpanun P, et al. Nematicidal activity of Fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita. World J Microbiol Biotechnol. 2011 Jun;27(6):1373-80.

Density	1.474g/cm3
Boiling Point	417.2ºC at 760 mmHg
Molecular Formula	C₇H₇N₅O₂
Molecular Weight	193.16300
Flash Point	206.1ºC
Exact Mass	193.06000
PSA	82.67000
Vapour Pressure	3.61E-07mmHg at 25°C
Index of Refraction	1.601

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7900000

CHEMICAL NAME :: Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-

CAS REGISTRY NUMBER :: 483-57-8

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H7-N5-O2

MOLECULAR WEIGHT :: 193.19

WISWESSER LINE NOTATION :: T66 BVNVN GNN JNJ C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,199,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,518,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 11200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

Precursor 6
25696-97-3 64-19-7 181585-32-0 134048-20-7
113613-78-8 62758-20-7
DownStream 4
30958-49-7 961-48-8 49738-24-1 24410-25-1

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.