3,4,5-trihydroxy-6-methylphthalaldehyde

Names

[ CAS No. ]:
483-53-4

[ Name ]:
3,4,5-trihydroxy-6-methylphthalaldehyde

[Synonym ]:
1,2-Benzenedicarboxaldehyde,3,4,5-trihydroxy-6-methyl
3,4,5-Trihydroxy-6-methyl-1,2-benzenedicarboxaldehyde
Phthalaldehyde,3,4,5-trihydroxy-6-methyl

Biological Activity

[Description]:

Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4+ T cells and CD11b+ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA[1]. Flavipin exhibits the DPPH free radical scavenging ability with IC50 value of 7.2 μM, and has potent α-glucosidase inhibition with IC50 value of 33.8 μM[2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. "Alzahrani A, et al. Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis. Saudi Pharm J. 2020;28(12):1605-1615. "

[2]. Li H, et al. Polyketides from two Chaetomium species and their biological functions. J Antibiot (Tokyo). 2018;71(7):677-681.

Chemical & Physical Properties

[ Density]:
1.577g/cm3

[ Boiling Point ]:
353.7ºC at 760mmHg

[ Molecular Formula ]:
C₉H₈O₅

[ Molecular Weight ]:
196.15700

[ Flash Point ]:
181.9ºC

[ Exact Mass ]:
196.03700

[ PSA ]:
94.83000

[ LogP ]:
0.73680

[ Vapour Pressure ]:
1.73E-05mmHg at 25°C

[ Index of Refraction ]:
1.741

Related Compounds

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