TFB-TBOA
Names
Biological Activity
[Description]:
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs[1].
[Related Catalog]:
[In Vitro]
TFB-TBOA (CF3-Bza-TBOA) inhibits synaptically activated transporter currents (STCs) in astrocytes in the stratum radiatum in rat hippocampal slices in a dose-dependent manner with an IC50 of 13 nM, and reduces them to approximately 10% of the control at 100 nM[2]. TFB-TBOA inhibits the Na+i response evoked by 200 µM glutamate in a concentration-dependent manner with IC50 value of 43 nM, as measured on the amplitude of the Na+i response[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H17F3N2O6
[ Molecular Weight ]:
426.34300
[ Exact Mass ]:
426.10400
[ PSA ]:
138.95000
[ LogP ]:
3.11270