Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (1R-(1a,7(2R,3S),7a-beta))-

Names

[ CAS No. ]:
480-82-0

[ Name ]:
Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester, (1R-(1a,7(2R*,3S*),7a-beta))-

[Synonym ]:
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate
2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester
lycopsamine
INDICINE
[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate

Biological Activity

[Description]:

Indicine (Compound 3) is an alkaloid. Indicine can reduce pyrrolizine alkaloids (PA) [1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Carpinelli de Jesus M, et al. Pyrrolizidine Alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and Their Presence in Australian Honey. J Agric Food Chem. 2019 Jul 17;67(28):7995-8006.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
463.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₅NO₅

[ Molecular Weight ]:
299.36

[ Flash Point ]:
234ºC

[ Exact Mass ]:
299.17300

[ PSA ]:
90.23000

[ Vapour Pressure ]:
1.57E-10mmHg at 25°C

[ Index of Refraction ]:
1.567

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7789900

CHEMICAL NAME :: Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)met hyl ester, (1R-(1a,7(2R*,3S*),7a-beta))-

CAS REGISTRY NUMBER :: 480-82-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H25-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 gm/kg/4W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg/9D-I

TOXIC EFFECTS :: Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

Precursor & DownStream

Precursor

DownStream

Related Compounds

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