AT2 receptor agonist C21

Names

[ Name ]:
AT2 receptor agonist C21

[Synonym ]:
Butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-isobutyl-2-thienyl}sulfonyl)carbamate
butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl}sulfonyl)carbamate
compound 21 [PMID: 22802221]
Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester
N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide

Biological Activity

[Description]:

AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1].

[Related Catalog]:

Research Areas >> Endocrinology

[Target]

Ki: 0.4 nM (AT2) and >10 µM (AT1)[1]

[In Vivo]

AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].

[References]

[1]. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₃H₂₉N₃O₄S₂

[ Molecular Weight ]:
475.624

[ Exact Mass ]:
475.159943

[ LogP ]:
4.93

[ Index of Refraction ]:
1.615

Related Compounds

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