AC-7954

Names

[ CAS No. ]:
477313-09-0

[ Name ]:
AC-7954

[Synonym ]:
ac-7954

Biological Activity

[Description]:

AC-7954 is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Urotensin Receptor

[References]

[1]. Croston GE, et al. Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954). J Med Chem. 2002 Nov 7;45(23):4950-3.

Chemical & Physical Properties

[ Boiling Point ]:
462.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₁Cl₂NO₂

[ Molecular Weight ]:
366.28200

[ Flash Point ]:
233.7ºC

[ Exact Mass ]:
365.09500

[ PSA ]:
29.54000

[ LogP ]:
4.70210

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Unraveling the active conformation of urotensin II.

J. Med. Chem. 47 , 1652-61, (2004)

Urotensin II (U-II) is a disulfide-bridged undecapeptide recently identified as the ligand of an orphan G-protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-cyclo[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH)...

Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).

J. Med. Chem. 45 , 4950-4953, (2002)

A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II receptor. Racemic 1 had ...