Antimycobacterial agent-4

Names

[ Name ]:
Antimycobacterial agent-4

Biological Activity

[Description]:

Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antimycobacterial agent-4 (compound 12) exerts antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain (MIC99=5 μM), and antiplasmodial activity against the Chloroquine (HY-17589A) sensitive NF54 Plasmodium falciparum strain (IC50=6.1 μM) and cytotoxicity on a mammalian cell line (CHO, IC50=2.2 μM)[1]. Antimycobacterial agent-4 (compound 38) shows cytotoxicity against Vero cells with toxic concentration TC50 of 3.0 μM[2].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₀N₄O₃S

[ Molecular Weight ]:
326.33

Related Compounds

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