Bis-(1,3-diethylthiobarbituric acid)trimethine oxonol

Names

[ CAS No. ]:
47623-98-3

[ Name ]:
Bis-(1,3-diethylthiobarbituric acid)trimethine oxonol

[Synonym ]:
DiSBAC2(3) [Bis-(1,3-diethylthiobarbituric acid) trimethine oxonol]
EINECS 256-325-5

Biological Activity

[Description]:

DiSBAC2(3) is an anionic membrane-potential-sensitive dye. DiSBAC2(3) is a plasma membrane potential indicator[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tatsuya Yoshimura, et al. Combined use of two membrane-potential-sensitive dyes for determination of the Galvani potential difference across a biomimetic oil/water interface. Anal Bioanal Chem. 2014 May;406(14):3407-14.

[2]. P Weisová, et al. Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability. Transl Psychiatry. 2013 Oct 22;3(10):e317.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
464.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₄N₄O₄S₂

[ Molecular Weight ]:
436.54800

[ Flash Point ]:
234.8ºC

[ Exact Mass ]:
436.12400

[ PSA ]:
145.42000

[ LogP ]:
0.82780

[ Index of Refraction ]:
1.684

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Membrane potential changes visualized in complete growth media through confocal laser scanning microscopy of bis-oxonol-loaded cells.

Exp. Cell Res. 231(2) , 260-8, (1997)

Confocal laser scanning microscopy (CLSM) was employed to visualize and measure membrane potential changes in several types of cultured adherent cells, such as human fibroblasts, mouse mammary tumor C...

Peroxynitrite affects Ca2+ influx through voltage-dependent calcium channels.

J. Neurochem. 76(2) , 341-50, (2001)

The effect of peroxynitrite (OONO-) on voltage-dependent Ca2+ channels (VDCCs) was examined by measuring [45Ca2+] influx into mouse cerebral cortical neurones. OONO- time- and dose-dependently increas...

Simultaneous mechanical stiffness and electrical potential measurements of living vascular endothelial cells using combined atomic force and epifluorescence microscopy.

Nanotechnology 20(17) , 175104, (2009)

The degree of mechanical stiffness of vascular endothelial cells determines the endogenous production of the vasodilating gas nitric oxide (NO). However, the underlying mechanisms are not yet understo...