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BAN ORL 24

Names

[ CAS No. ]:
475150-69-7

[ Name ]:
BAN ORL 24

[Synonym ]:
2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H),4'-piperidin]-1'-ylpropyl)-, (2R)-, hydrochloride (1:2)
1-Benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide dihydrochloride
BAN ORL 24

Biological Activity

[Description]:

BAN ORL 24 free base is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 free base has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 free base can be used for the research of cancer and analgesic[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[References]

[1]. Tao Hou, et al. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. J Ethnopharmacol  

[2]. Chao, et al. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology 166, 107678 (2020).

[3]. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H35N3O2

[ Molecular Weight ]:
433.59

[ Exact Mass ]:
505.226288

Related Compounds