C12-NBD Sphinganine

Names

[ Name ]:
C12-NBD Sphinganine

[Synonym ]:
N-[(2S,3R)-1,3-Dihydroxy-2-octadecanyl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanamide
Dodecanamide, N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-

Biological Activity

[Description]:

C12-NBD Sphinganine is a fluorescent ceramidase substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rigogliuso S, et al. An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines. J Oncol. 2010;2010:509329.

[2]. Okino N, et al. Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis. Biosci Biotechnol Biochem. 2010;74(2):316-21.

[3]. Vijai Kumar Reddy T, et al. Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. Eur J Med Chem. 2016 Aug 8;118:98-106.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Molecular Formula ]:
C₃₆H₆₃N₅O₆

[ Molecular Weight ]:
661.915

[ Exact Mass ]:
661.477844

[ PSA ]:
169.82000

[ LogP ]:
11.57

[ Index of Refraction ]:
1.540

Safety Information

[ Hazard Codes ]:
T+

Related Compounds

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