5MPN

Names

[ Name ]:
5MPN

[Synonym ]:
5-[(8-Methoxy-4-quinolinyl)amino]pentyl nitrate
MFCD00089445
5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE
1-Pentanol, 5-[(8-methoxy-4-quinolinyl)amino]-, nitrate (ester)

Biological Activity

[Description]:

5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3; suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro, suppresses the glucose metabolism and growth of tumors in mice.

[References]

References 1. Chesney J, et al. Oncotarget. 2015 Jul 20;6(20):18001-11. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
493.8±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₉N₃O₄

[ Molecular Weight ]:
305.329

[ Flash Point ]:
252.4±27.3 °C

[ Exact Mass ]:
305.137543

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.607

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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