N-Phthaloylglycine

Names

[ Name ]:
N-Phthaloylglycine

[Synonym ]:
PHTHALYL GLYCINE
Phthalimidoacetic acid
N-Phthaloylglycine
n-phthalylglycin
2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-
N-phtaloyl glycine
1,3-Dioxo-2-isoindolineacetic acid
2-phthalimidoacetic acid
PHT-GLY-OH
PHTHALOYLGLYCINE
(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid
Phthaloglycine
N-PHTHALOGLYCINE
N-Phthalimidoacetic Acid
MFCD00005900
1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid
phthalimidomethylcarboxylic acid
EINECS 225-177-3

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
412.6±28.0 °C at 760 mmHg

[ Melting Point ]:
193-196 °C(lit.)

[ Molecular Formula ]:
C₁₀H₇NO₄

[ Molecular Weight ]:
205.167

[ Flash Point ]:
203.3±24.0 °C

[ Exact Mass ]:
205.037506

[ PSA ]:
74.68000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR3439000

CHEMICAL NAME :: 2-Isoindolineacetic acid, 1,3-dioxo-

CAS REGISTRY NUMBER :: 4702-13-0

BEILSTEIN REFERENCE NO. :: 0184174

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H7-N-O4

MOLECULAR WEIGHT :: 205.18

WISWESSER LINE NOTATION :: T56 BVNVJ C1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 28,680,1973

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S22-S24/25-S36/37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NR3439000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

N-phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats.

Acta. Pharm. 58(2) , 231-6, (2008)

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal ap...

Comparative pharmacokinetic and pharmacodynamic analysis of phthaloyl glycine derivatives with potential antiepileptic activity.

Pharm. Res. 11(10) , 1429-34, (1994)

Glycine, in addition to GABA, is one of the most important neurotransmitter amino acids. The described structure pharmacokinetic pharmacodynamic relationships (SPPR) study explored the possibility of ...

Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine.

J. Photochem. Photobiol. B, Biol. 117 , 228-39, (2012)

Ni(II), Cu(II) and Zn(II) metal complexes of N-phthaloylglycine were synthesized, characterized, reported for single crystal X-ray diffraction analysis for Ni(II) complex, and investigated for their b...