Marinobufogenin
Names
[ CAS No. ]:
470-42-8
[ Name ]:
Marinobufogenin
[Synonym ]:
(3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide
5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy-
5beta-Bufa-20,22-dienolide,14,15beta-epoxy-3beta,5-dihydroxy
Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-,(3beta,5beta,15beta)
Marinobufagenin
Marinobufogenin
Marinobufagin
Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)-
MARCINOBUFAGIN
5-hydroxyl-resibufogenin
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: Na+/K+ ATPase[1]
[References]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
589.0±50.0 °C at 760 mmHg
[ Molecular Formula ]:
C24H32O5
[ Molecular Weight ]:
400.508
[ Flash Point ]:
203.0±23.6 °C
[ Exact Mass ]:
400.224976
[ PSA ]:
83.20000
[ LogP ]:
1.25
[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C
[ Index of Refraction ]:
1.621
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EI2963000
- CHEMICAL NAME :
- 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy-
- CAS REGISTRY NUMBER :
- 470-42-8
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C24-H32-O5
- MOLECULAR WEIGHT :
- 400.56
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2730 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1520 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 556 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963
Safety Information
[ Hazard Codes ]:
Xi