AFP464

Names

[ CAS No. ]:
468719-52-0

[ Name ]:
AFP464

[Synonym ]:
AFP-464 free base
Hexanamide,2,6-diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-1-benzopyran-2-yl)-2-fluorophenyl)-,(2S)
UNII-O3HFV0VQ36

Biological Activity

[Description]:

AFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Research Areas >> Cancer

[Target]

IC50：0.25 μM (HIF-1α)[1]


[References]

[1]. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48.


[Related Small Molecules]

Dimethyloxalylglycine | PT-2385 | FG-4592 | PX-478 2HCl | BAY 87-2243 | Vadadustat | Daprodustat | Oltipraz | Chlorogenic acid | LW 6 | Molidustat | IOX2 | Paeoniflorin | KC7F2 | oroxylin A

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23F3N4O3

[ Molecular Weight ]:
448.44

[ PSA ]:
203.61000

[ LogP ]:
6.37880

Related Compounds